To assess the effect of a nutrition education intervention on nutritional factors and oxidative stress during treatment of breast cancer.
Nonrandomized clinical trial conducted in 2010–2011, including an evaluation at baseline and after 12 months.
Women from Brazil who had breast cancer, divided into an intervention group (IG) (n = 18) and comparison group (n = 75).
To increase intake of fruits and vegetables and reduce red and processed meats, via telephone and printed materials.
Main Outcome Measures
Food intake, anthropometry, and levels of lipid hydroperoxide, carbonyl proteins, reduced glutathione, and ferric reducing antioxidant power.
Chi-square, Mann–Whitney or t tests for baseline data; Wilcoxon or paired t tests for intra-group outcomes, linear regression models, and Bonferroni multiplicity adjustment.
The researchers observed an increase in fruit and vegetable intake, reduction in red and processed meat intake, no change in body weight, and an increase in glutathione in the IG over the comparison group. However, after Bonferroni adjustment, only the consumption of fruits and vegetables and fruit was significantly higher in IG.
Conclusions and Implications
This study presents improved dietary changes after a theory-driven nutrition education intervention. Although the sample size is small, it has proven to be clinically relevant.
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- Estimativa 2012: Incidência de Câncer no Brasil/Instituto Nacional de Câncer.INCA, Rio de Janeiro, Brasil2011
- Cancer survival in five continents: a worldwide population-based study (CONCORD).Lancet Oncol. 2008; 9: 730-756
- Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer.Cancer Epidemiol Biomarkers Prev. 2007; 16: 200-215
- Diet and biomarkers of oxidative damage in women previously treated for breast cancer.Nutr Cancer. 2005; 51: 146-154
- Dietary intake and oxidative stress in breast cancer: before and after treatments.Nutr Hosp. 2011; 26: 737-744
- Weight loss in breast cancer patient management.J Clin Oncol. 2002; 20: 1128-1143
- Achieving substantial changes in eating behavior among women previously treated for breast cancer—An overview of the intervention.J Am Diet Assoc. 2005; 105: 382-391
- Telephone counseling helps maintain long-term adherence to a high-vegetable dietary pattern.J Nutr. 2007; 137: 2291-2296
- The evolution of social cognitive theory.in: Smith K.G. Hitt M.A. Great Minds in Management. Oxford University Press, Oxford, United Kingdom2005: 9-35
- Energy balance in women with breast cancer during adjuvant treatment.J Am Diet Assoc. 1999; 99: 1222-1227
- Food, Nutrition, and the Prevention of Cancer: a Global Perspective.American Institute for Cancer Research, Washington, DC2007
- Gene-nutrient interactions in cancer etiology.Nutr Rev. 2004; 62: 427-438
- Factors associated with oxidative stress in women with breast cancer.Nutr Hosp. 2011; 26: 528-536
- Fatores que influenciam o consumo energético de mulheres no tratamento do câncer de mama.Rev Bras Ginecol Obstet. 2011; 33: 207-213
- Increased body weight and blood oxidative stress in breast cancer patients after adjuvant chemotherapy.Breast J. 2013; 19: 555-557
- Registro Fotográfico para Inquéritos Dietéticos: Utensílios e Porções.UNICAMP, Goiânia, Campinas, SP1996
- Memory and its role in appetite regulation.Physiol Behav. 2005; 85: 67-72
- Validity of a Brazilian frequency questionnaire against dietary recalls and estimated energy intake.Nutr Res. 1998; 19: 1649-1659
- Physical status: the use and interpretation of anthropometry.WHO, Geneva, Switzerland1995 (WHO Technical Report Series 854)
- Improved method for the determination of blood glutathione.J Lab Clin Med. 1963; 61: 882-890
- The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay.Anal Biochem. 1996; 239: 70-76
- Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine.Anal Biochem. 1994; 220: 403-409
- Determination of carbonyl content in oxidatively modified proteins.Methods Enzymol. 1990; 186: 464-478
- Resgate do conceito de aconselhamento no contexto do atendimento nuticional.Rev Nutr. 2005; 18: 119-128
- Significant changes in dietary intake and supplement use after breast cancer diagnosis in a UK multicentre study.Breast Cancer Res Treat. 2011; 128: 473-482
- A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: the Women's Healthy Eating and Living (WHEL) Study.Control Clin Trials. 2002; 23: 728-756
- Lifestyle factors and survival in women with breast cancer.J Nutr. 2007; 137: 236S-242S
- Quality of life among women recently diagnosed with invasive breast cancer: the Pathways study.Breast Cancer Res Treat. 2010; 123: 507-524
- Increase fruit, vegetable and fiber intake and lower fat intake report among women previously treated for invasive breast cancer.J Am Diet Assoc. 2002; 102: 801-808
- Disparities by education level in outcomes of a self-management intervention: the DELTA trial in The Netherlands.Psychiatr Serv. 2011; 62: 793-795
- Interventions designed to increase adult fruit and vegetable intake can be effective: a systematic review of the literature.J Nutr. 2005; 135: 2486-2495
- Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study.J Natl Cancer Inst. 2006; 98: 1767-1776
- Weight, weight gain, and survival after breast cancer diagnosis.J Clin Oncol. 2005; 23: 1370-1378
- Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.Clin Breast Cancer. 2008; 8: 70-79
- Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis.J Clin Oncol. 1999; 17: 120-129
- Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide.Clin Biochem. 2010; 43: 1287-1293
- Differential oxidative status and immune characterization of the early and advanced stages of human breast cancer.Breast Cancer Res Treat. 2012; 133: 881-888
- Preventing sarcopenic obesity among breast cancer patients who receive adjuvant chemotherapy: results of a feasibility study.Clin Exerc Physiol. 2002; 4: 44-49
Accepted: September 19, 2014
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